Daclizumab 生物类似药, CD25 单克隆抗体

背景资料

Daclizumab Biosimilar uses the same protein sequences as the therapeutic antibody daclizumab. Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. The murine sequences were derived from the complementarity-determining regions of a murine anti-Tac antibody. Daclizumab binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes.

应用类型

Flow cytometry, animal model study

免疫原

Human CD25

宿主

CHO cells

反应性

Human

保存条件

Store at 4°C 1 month, store at -20°C to -70°C 12 month. protected from prolonged exposure to light. Avoid freeze/thaw cycles.

品牌介绍

Interleukin-2 receptor alpha chain, CD25, IL2RA, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha

FAQ

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