Galiximab 生物类似药, CD80 单克隆抗体

背景资料

A humanized IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. Galiximab binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies. Galiximab, an IgG(1) anti-CD80 antibody, binds to CD80, a costimulatory molecule involved in T-cell activation. Reduction in lesional, activated T cells induces improvement in psoriatic plaques.

应用类型

Flow cytometry, animal model study

免疫原

Human CD80

宿主

CHO cells

反应性

Human

保存条件

Store at 4°C 1 month, store at -20°C to -70°C 12 month. protected from prolonged exposure to light. Avoid freeze/thaw cycles.

品牌介绍

Cluster of differentiation 80, CD80, B7-1, B7, B7.1, BB1, CD28LG, CD28LG1, LAB7

FAQ

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