2-cyano-3，12-dioxo-oleana-1，9（11）-dien-28-oic acid； Bardoxolone | RTA 401； CDDO

背景资料

CDDO is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By suppressing reactive oxygen and nitrogen species （ROS/RNS） formation， it promotes the cellular control of ROS/RNS levels that would lead to DNA damage associated with tumorigenesis. In various cancer cell lines， CDDO has been shown to specifically inhibit proliferation and induce apoptosis. Mechanism studies revealed that CDDO is a ligand for peroxisome proliferator-activated receptor γ， and also that it induces genes regulated by Nrf2， including heme oxygenase-1 and eotaxin-1， which play a role in antioxidant response element signaling activity.

保存条件

建议您在收到Cayman Chemical品牌的CDDO （10 mg）产品后置于-20度保存，产品有效期为730天.

品牌介绍

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，艾美捷科技有限公司将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

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